To prevent abdominal aortic aneurysm (AAA) (abdominal aortic aneurysm), attention must be paid to reducing individual risk factors.
Behavioral risk factors
- Pleasure food consumption
- Alcohol consumption – People with a genetic predisposition to alcohol consumption are 2.6 times more likely to suffer an abdominal aortic aneurysm (evidence from Mendelian randomization).
- Nicotine abuse (routine screening for early detection of abdominal aortic aneurysm is recommended in older male smokers or ex-smokers!).
Note: Control of blood pressure and therapy for hypertension (high blood pressure) should be performed in all patients with AAA to prevent cardiovascular complications. Level of evidence 1a/grade of recommendation A [S3 guideline].
Note: Abdominal aortic aneurysm screening (BAA screening) is recommended for all men older than 65 years in Germany. The prevalence (disease incidence) of BAA is 1.5% annually. The mortality (death rate) of ruptured abdominal aortic aneurysm (BAA) is high, as high as 80%.
Prevention Factors
- Genetic factors:
- Genetic risk reduction depending on gene polymorphisms:
- Genes/SNPs (single nucleotide polymorphism):
- SNP: rs10757278 in an intergenic region [cerebral aneurysm and abdominal aortic aneurysm].
- Allele constellation: AA (0.77-fold).
- SNP: rs10757278 in an intergenic region [cerebral aneurysm and abdominal aortic aneurysm].
- Genes/SNPs (single nucleotide polymorphism):
- Genetic risk reduction depending on gene polymorphisms:
