Products
Acenocoumarol is commercially available in tablet form (Sintrom, Sintrom mitis). It has been approved in many countries since 1955.
Structure and properties
Acenocoumarol (C19H15NO6, Mr = 353.3 g/mol) is a 4-hydroxycoumarin derivative. It is present in the drug as a racemate.
Effects
Acenocoumarol (ATC B01AA07) has anticoagulant and antithrombotic properties. The effects are due to inhibition of vitamin K epoxide reductase. Phytomenadione (vitamin K1) can be used as an antidote.
Indications
For the prevention and treatment of thromboembolic disease.
Dosage
According to the professional information. The dose must be adjusted individually and checked regularly. Tablets are taken once daily and always at the same time of day.
Contraindications
- Hypersensitivity
- Pregnancy
- Lack of cooperation
- Risk of severe bleeding
For complete precautions, see the drug label.
Interactions
Acenocoumarol is metabolized primarily by CYP2C9. It has a high potential for drug-drug interactions.
Adverse effects
The most common potential adverse effects include bleeding.
