Products
Allantoin is found in creams and ointments for external use and in numerous cosmetics and personal care products.
Structure and properties
Allantoin (C4H6N4O3, Mr = 158.12 g/mol) is a racemate and belongs to the group of imidazolidines. It is present white, crystalline powder and is odorless and tasteless. It is sparingly soluble in water. Allantoin is an end product of purine metabolism in plant and animal organisms and is formed by the enzyme uricase during the oxidative breakdown of uric acid. It occurs naturally, for example, in comfrey, maple, salsify, beets, horse chestnuts, and in wheat germ.
Effects
Allantoin promotes cell proliferation, epithelial formation, and removes necrotic tissue. It has anabolic, antioxidant, moisturizing, smoothing, keratolytic, penetration-promoting, and antimutagenic properties.
Indications
Allantoin is used externally for wound treatment (cuts, burns, ulcers, eczema, etc.), skin care, against skin diseases, and for scar care. It is often included in medicines to soften the skin and facilitate the penetration of active ingredients.
Dosage
According to the package insert.
Contraindications
Allantoin is contraindicated in cases of hypersensitivity. For complete precautions and information on interactions, see the drug label.
Adverse effects
Possible adverse effects include hypersensitivity reactions.
