Alternatives to SGLT2 inhibitors?

There is a wide range of possible preparations in the treatment of diabetes mellitus type 2, the first group being the sulfonylureas, which cause an increase in insulin secretion. The second group are glinides, which also increase insulin secretion. The incretins also promote the release of insulin.

Metformin acts directly on the body cells and reduces, for example, the production of new sugar from the liver‘s reserves. Glitazones increase the sensitivity of body cells to insulin. Alpha-glucosidase inhibitors reduce the absorption of sugar in the intestine. The last resort is always the artificial supply of insulin.

Taking during pregnancy and lactation

Studies in animal studies have shown that SGLT2 inhibitors have an inhibitory effect on the development of the unborn child’s kidneys. Therefore, these drugs should not be used, especially in the second and third trimesters. As soon as pregnancy is known, the medication should be discontinued. Since it cannot be ruled out that the active ingredient may also be transferred into breast milk and thus pose a risk to the child, SGLT2 inhibitors should not be used during the breastfeeding period either.

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