Aminomethylbenzoic acid is used as an active ingredient for blood clotting. It is thus of great value in cases of massive hemorrhage. The drug can also be used in the resulting sequelae.
What is aminomethylbenzoic acid?
Aminomethylbenzoic acid is used as an active ingredient to coagulate blood. Thus, it is of great value in cases of massive bleeding. When wounds occur and the bleeding that accompanies them, the organism should be able to help itself. In these cases, the so-called plasmin would be formed, which is involved in the coagulation of blood. However, in some acute and chronic initial conditions, the body may no longer be ready to produce this enzyme. It is therefore necessary to inhibit bleeding with a drug. Aminomethylbenzoic acid is often used for this purpose. It is administered orally in the form of tablets and capsules. The effect takes place about 60 to 120 minutes after the preventive ingestion and lasts for about five hours. This time is regularly sufficient to stop even heavier bleeding and to coagulate the blood. Subsequent excretion is virtually residue-free via the kidneys. Apart from minor side effects, the drug is also usually very well tolerated.
Pharmacologic action
Aminomethylbenzoic acid is deposited in the organism at the plasminogen binding site. This molecule is occupied by plasmin in a healthy body during the formation of a wound. Plasmin in turn forms a proenzyme at this site, which supports fibrin cleavage, which in turn forms the basis for blood clotting. However, not every organism is capable of this. Thus, in the context of acute conditions as well as chronic complaints, lysine can bind to the plasminogen binding site. The effect of this would be to prevent the aforementioned process. The blood would leave the wound without clotting. Self-healing and thus closure of the wound would not be possible. However, the aminomethylbenzoic acid now blocks the plasminogen binding site. Consequently, lysine can no longer accumulate at this site. The way is paved for fibrin cleavage and the associated blood clotting. However, the effect lasts only for a few hours. Subsequently, the wound is closed, so that repeated lysine deposition at the binding site is no longer able to trigger a negative result.
Medical application and use
Aminomethylbenzoic acid is of great importance in fibrinolysis – the breakdown of a blood clot triggered in the body. As a result, uncontrolled bleeding would otherwise occur. Since these can reach a very high intensity, the course of even minor wounds would sometimes be fatal, depending on the initial situation. It is irrelevant whether the disturbance in the organism is chronic or temporary and localized. Even one tablet in an average dosage can therefore stop bleeding within one to two hours. Going further, administration in the context of hemophilia A would have to be considered. The coagulation of the blood is also inhibited in this condition. An additional possible application is in prostate carcinoma. Here, in the course of tumor growth, blood can leak out. This is usually detected in the urine and stool. Here, too, aminomethylbenzoic acid has a coagulating effect. In a few forms of blood cancer, ingestion is likewise relied upon.
Risks and side effects
Aminomethylbenzoic acid can lead to undesirable side effects in the days following initial ingestion. These usually take place in the area of the stomach and intestines. Thus, the side effects are often accompanied by diarrhea and vomiting. In addition, dizziness can occur. In general, a decreased sense of well-being is perceived. Tiredness, headaches and lack of drive dominate. Not infrequently, a rapid drop in blood pressure is also recorded. In addition, it is important not to administer aminomethylbenzoic acid to certain groups of people and when certain medical indications occur. These include pregnancy with subsequent breastfeeding, so-called vitreous humor disease, weakening or even functional incapacity of the kidneys, and a general tendency to thrombosis. Finally, it should be noted that aminomethylbenzoic acid is also suitable for interaction with other drugs.This could result in negative circumstances.
