Products
Aminorex was approved in many countries in 1965 and withdrawn from the market in 1972 due to adverse effects (Menocil).
Structure and properties
Aminorex (C9H10N2O, Mr = 162.2 g/mol) is a dihydrooxazolamine structurally related to amphetamines.
Effects
Aminorex has appetite suppressant properties. The effects are due to the release of catecholamines.
Indications
For the treatment of overweight and obesity.
Abuse
The derivative 4-methylaminorex (“Euphoria”) is abused as an illegal narcotic.
Adverse effects
The drug has led to an increase in cases of pulmonary arterial hypertension and caused numerous deaths during the years of its approval.
