Products
Amphotericin B is available in tablet, lozenge, suspension, and injection forms (Ampho-Moronal, Fungizone). It has been approved in many countries since 1964. This article refers to its use in the mouth and digestive system.
Structure and properties
Amphotericin B (C47H73NO17, Mr = 924 g/mol) is a mixture of antifungal polyenes obtained from certain strains of . It is a yellow to orange, hygroscopic powder that is practically insoluble in water.
Effects
Amphotericin B (ATC A01AB04, ATC A07AA07) has antifungal properties and is particularly effective against Candida albicans, related yeasts, and. Several molecules together form pores in the cell membrane of fungi, leading to their dissolution. When administered orally, it is barely absorbed and acts mainly locally in the intestine.
Indications
For the treatment of fungal infections with Candida and other yeasts in the oral cavity (oral thrush) and in the digestive tract.
Dosage
According to the SmPC. Medicines are usually applied 4 times a day.
Contraindications
Amphotericin B is contraindicated in cases of hypersensitivity. The oral drugs must not be used to treat systemic diseases. Refer to the drug label for complete precautions.
Interactions
There are no known drug-drug interactions.
Adverse effects
The most common possible adverse effects include hypersensitivity reactions, inflammation of the tongue, nausea, vomiting, diarrhea, and skin rashes.
