Products
Amygdalin is not approved as a drug in many countries. The German Federal Institute for Drugs and Medical Devices (BfArM) classifies it as a “drug of concern.”
Structure and properties
-Amygdalin (C20H27NO11, Mr = 457.4 g/mol) is a cyanogenic glycoside found in relatively high concentrations in the seeds of many stone fruits. These include bitter almonds, cherries, bitter apricots, peaches, plums, and apples. The seeds are found in the stone core of the fruit.
Effects
Upon disruption of cell integrity, amygdalin is enzymatically converted to hydrocyanic acid (cyanide), which is toxic. When administered orally, the substance is metabolized by intestinal bacteria. According to the literature, amygdalin has no antitumor properties and is unsuitable as an anticancer agent. Amygdalin has also been referred to as vitamin B17, but it is not a vitamin.
Indications for use
Amygdalin and bitter apricot kernels have been touted as a natural anticancer agent. However, this is strongly discouraged due to toxicity.
Dosage
According to the German Federal Office for Risk Assessment (BfR), adults should not take more than two bitter apricot kernels per day. Children should refrain from consuming them.
Adverse effects
Amygdalin and amygdalin-containing seeds can cause severe poisoning and death:
- Convulsions
- Liver damage
- Gait disorders, neuropathies
- Fever, headache, dizziness
- Vomiting, nausea
- Low blood pressure
- Confusion
- Respiratory distress, cyanosis, fatal respiratory paralysis.
- Coma
