Products
Anethole trithione is commercially available in the form of dragées (Sulfarlem S25). It has been approved in many countries since 1973.
Structure and properties
Anethole trithione (C10H8OS3, Mr = 240.4 g/mol) is a dithiol-3-thione derivative of anethole, the main ingredient of anise and fennel essential oils. It is present in the form of bitter-tasting, orange crystals that are practically insoluble in water.
Effects
Anetholtrithione (ATC A16AX02) is effective against dry mouth and is a choleretic. It is an older drug for which no modern registration studies are available. In our view, the drug is insufficiently documented.
Indications
For the treatment of dry mouth of various causes.
Dosage
According to the professional information. The drug is usually administered three times a day and before meals.
Contraindications
- Hypersensitivity
- Obstruction of the bile ducts
- Severe liver dysfunction
Full precautions can be found in the drug label.
Interactions
No drug-drug interactions are known to date.
Adverse effects
Possible adverse effects include digestive symptoms such as diarrhea, hypersensitivity reactions, and harmless urinary discoloration.