Definition
Antifibrinolytics are drugs that inhibit the dissolution of fibrin and thus the development of bleeding.
Effects
Antifibrinolytic: inhibit the dissolution of fibrin and reduce blood loss due to generalized or locally increased fibrinolytic activity.
Mechanism of action
Antifibrinolytics are direct or indirect inhibitors of plasmin, which cleaves fibrin.
Agents
Amino acids:
- Tranexamic acid (Cyklokapron).
Plasmin inhibitor:
- Aprotinin (Trasylol, out of commerce).
