Synonyms in a broader sense
Angiotensin receptor blocker, Sartane English: antagonists of angiotensin 2
Effect
Atacand® belongs to the AT1 receptor antagonists, another group of blood pressure drugs that also attack the renin-angiotensin-aldosterone system. Compared to ACE inhibitors, however, they have a different point of attack, namely the receptor of angiotensin 2, through which it attains its effect. This receptor is called the AT1 receptor and is blocked by the blood pressure medication so that angiotensin II can no longer act. As a result, blood pressure is lowered by the same mechanisms as with ACE inhibitors.
Side effects
When taking Atacand®, the risk of developing hyperkalemia (elevated potassium levels) is increased and kidney values may rise. In addition, blood pressure may drop (hypotension) and patients may feel dizzy. However, compared to ACE inhibitors, coughing or angioedema (Quicke’s edema) is rare.
Interactions
Atacand® has basically the same interactions as ACE inhibitors.
Fields of application
Atacand® is used like an ACE inhibitor to treat high blood pressure (arterial hypertension) and chronic heart failure (chronic heart failure). Compared with ACE inhibitors, which are also used to treat these diseases, they are better tolerated. However, as long-term experience is still lacking, ACE inhibitors are prescribed preferentially and the AT1 antagonists are mainly used in cases of intolerance.
Contraindications
Pregnant and breastfeeding women must not take these antihypertensive drugs as they have a lethal effect on the unborn child. In addition, Atacand® should not be used for kidney diseases, namely for functional disorders or narrowing of the renal artery (renal artery stenosis). A combination with potassium-saving diuretics or the simultaneous administration of potassium should also be avoided.
Finally, there is a contraindication for certain heart diseases. These include heart valve defects (aortic valve stenosis, mitral valve stenosis) and cardiomyopathy.
