Products
Basmisanil is in clinical development at Roche and is not yet commercially available.
Structure and properties
Basmisanil (C
21
H
20
FN
3
O
5
S, M
r
= 445.5 g/mol) is a pyridine, thiomorpholino and oxazole derivative.
Effects
Basmisanil is a negative allosteric modulator at the α5-subunit of GABA
A
-receptor. It reduces the increased activity of the inhibitory neurotransmitter GABA in the central nervous system, allowing improvement of cognitive abilities.
Indications
To improve cognitive abilities in people with Down syndrome.
Dosage
The drug is administered perorally. It is intended to be used primarily in children, according to the approval.
