Beloc Zok Mite

Metoprolol

General information

Beloc Zok Mite® contains the active ingredient metoprolol in a dose of 47.5 mg. Further doses are 95 mg (Beloc Zok®) and 190 mg (Beloc Zok forte®). The drug is a so-called retard preparation, which means that the active ingredient is released in the body with a delay. On the one hand, the effect lasts longer, and on the other hand, the occurrence of sudden very high drug concentrations is avoided, which in turn reduces the risk of side effects.

Metoprolol belongs to the group of beta-blockers. It is widely used in the treatment of cardiovascular diseases but also for the preventive treatment of migraine (migraine prophylaxis). Metoprolol is one of the most frequently used beta-blockers in Germany.

Application and indication

Belok Zok Mite® is used for the treatment of high blood pressure (arterial hypertension), coronary heart disease (CHD), tachycardic arrhythmias (i.e. arrhythmias where the heart beats too fast), chronic compensated (i.e. stable) heart failure, functional heart problems and for migraine prophylaxis. Beta-blockers reduce mortality after acute myocardial infarction and are used here at an early stage – provided the patient is stable. They also play an important role in the prophylaxis of reinfarction after myocardial infarction and are used as standard, provided that there are no contraindications.

Dosage of Beloc Zok Mite®

The dose depends on the disease to be treated with Beloc Zok Mite®. It is essential to note that the therapy with Beloc Zok Mite® must not be interrupted abruptly, as this increases the risk of a heart attack or sudden cardiac death significantly. – For high blood pressure, coronary heart disease and functional heart complaints, the usual daily dose is 50-100 mg metoprolol, taken in 1-2 single doses.

The maximum daily dose is 200 mg.

  • For cardiac arrhythmia, reinfarction prophylaxis and migraine prophylaxis, daily doses of between 100 and 200 mg are administered, again in 1-2 single doses. – In acute myocardial infarction – provided the patient is stable – 5 mg Belok Zok Mite® is administered intravenously at the beginning, which can be repeated at intervals of a few minutes. The maximum dose is 15 mg intravenously. If the dose is well tolerated, a switch to oral administration in the form of tablets should be made; here a dose of 25-50 mg should be started. If this is tolerated, the dose is increased individually to 100-200 mg within 48 hours.

Side effects

Especially at the beginning of the treatment with Belok Zok Mite® the following side effects may occur: Due to the effect on the heart, treatment with Belok Zok Mite® can lead to a drop in blood pressure (hypotension), sometimes even to a brief loss of consciousness (syncope). An excessive slowing down of the heartbeat (bradycardia), palpitations (palpitations) and cardiac conduction disorders can occur. Beta-blockers can lead to an increase in blood lipids (triglycerides) and thus increase the risk of arteriosclerosis.

In the case of pre-existing heart failure, it can – especially at the beginning of treatment and if the dose is too high – lead to an increase in cardiac insufficiency. This is manifested by increased water retention in the legs (lower leg edema) and shortness of breath (dyspnoea). Belok Zok Mite® can promote hypoglycaemia in pre-existing diabetes mellitus and disguise the warning symptoms (sweating, trembling, palpitations).

It should therefore only be used cautiously and under regular supervision in diabetics. Beta-blockers can lead to a narrowing of the airways (bronchoconstriction), this is particularly important in patients with chronic obstructive respiratory diseases. Beta-blockers are contraindicated in bronchial asthma.

Patients with Raynaud’s syndrome (circulatory disorders of the fingers) may experience a worsening of the symptoms, therefore Belok Zok Mite® should be used with caution in this case. The same applies to patients with peripheral arterial occlusive disease (PAD, shop window disease). Treatment with Belok Zok Mite® should also be carried out with caution in patients with psoriasis or family members with psoriasis, as a worsening of an already existing psoriasis or a new occurrence of psoriasis can be favoured. – Fatigue, sleep disturbances and nightmares

  • Vertigo
  • Headaches
  • Confusion
  • Gastrointestinal complaints such as nausea, vomiting and diarrhoea
  • Hypersensitivity reactions of the skin: rash, redness, itching
  • Tingling in the limbs (paresthesia)