Products
Benproperine is commercially available in the form of tablets (Tussafug). The drug is not registered in many countries.
Structure and properties
Benproperine (C21H27NO, Mr = 309.4 g/mol) is a piperidine derivative. It is present in the drug as a racemate and benproperine phosphate.
Effects
Benproperine (ATC R05DB02) has antitussive properties. It is not opioid and does not attenuate respiration but, on the contrary, tends to stimulate it. Its effects are due to inhibition of the coughing stimulus in the afferent part of the reflex arc.
Indications
For the treatment of irritable cough.
Dosage
According to the professional information. The tablets are usually taken two to four times daily.
Contraindications
Benproperine is contraindicated in case of hypersensitivity. Full precautions can be found in the drug label.
Interactions
No information is available on interactions with other drugs.
Adverse effects
Possible adverse effects include drowsiness, nausea, and dry mouth. These side effects occur very rarely.
