Active substance
Aceclofenac
General information
Beofenac® is a drug that contains the active ingredient aceclofenac. It is an analgesic and belongs here to the group of non-steroidal anti-inflammatory drugs (NSAID) or non-steroidal anti-inflammatory drugs (NSAID). Drugs in this group have an additional antipyretic effect.
Ibuprofen and diclofenac, for example, also belong to the NSAID group. Beofenac® is used, among other things, to treat the symptoms of rheumatic diseases. – anti-inflammatory (antiphlogistic/antirheumatic) and
- Analgesic (analgesic),
Side effects of Beofenac®
Side effects often occur when taking Beofenac® that affect the gastrointestinal tract. Among other things: One of the most important complications that can occur while taking NSAIDs in general is inflammation of the stomach lining (gastritis) with the development of stomach ulcers and the risk of bleeding in the gastrointestinal tract (gastrointestinal bleeding). Side effects that manifest themselves in the central nervous system include dizziness, headaches, fatigue, and hearing and vision problems.
Since drugs from the NSAID group retain water in the body (water retention), treatment can lead to water retention (edema), an increase in blood pressure (hypertension) and deterioration of already limited kidney and heart function (heart failure). Hypersensitivity reactions can rarely occur, for example in the form of skin reactions (exanthema) or an “analgesic asthma” (narrowing of the airways when taking NSAIDs). Blood formation disorders as well as liver and kidney dysfunction can also occur. – Nausea,
- Stomachache,
- Digestive disorders and
- Diarrhoea (diarrhoea) but also constipation (constipation).
Interactions
Aceclofenac, by retaining water in the body, can reduce the effect of water tablets (diuretics) that cause water to be washed out. Drugs that lower blood pressure (antihypertensives) can also be reduced by aceclofenac. Furthermore, a combination of aceclofenac with diuretics can lead to a deterioration in kidney function, as can a combination with ACE inhibitors to treat heart disease and high blood pressure.
When aceclofenac is combined with digoxin (drug for the treatment of heart failure), lithium (treatment of mental illness) and methotrexate (immunosuppressant), the excretion of these drugs through the kidneys can be inhibited, thus increasing their effectiveness. Drugs such as: are also broken down more slowly when aceclofenac is taken at the same time and therefore have a stronger effect. If the immunosuppressive drugs tacrolimus and ciclosporin are taken at the same time, there is an increased risk of kidney damage (nephrotoxicity). The simultaneous intake of glucocorticoids (e.g. cortisone) increases the risk of gastrointestinal ulcers many times over. – Cimetidine (inhibition of gastric acid secretion),
- Amiodarone (heart rhythm disturbances),
- Tolbutamide (antidiabetic) and other
Application/indications
Beofenac® is used to relieve pain and inhibit inflammation:
- Arthrosis (degenerative joint disease),
- Rheumatoid arthritis (“rheumatism”) and
- Ankylosing spondylitis (ankylosing spondylitis).
Dosage
The maximum dose is 200 mg per day, which corresponds to 2 tablets of 100 mg each, taken in the morning and evening. In case of reduced liver function, the maximum daily dose is 100 mg.
