The United Kingdom Expert Group on Vitamins and Minerals (EVM) last assessed vitamins and minerals for safety in 2003 and set a so-called Safe Upper Level (SUL) or Guidance Level for each micronutrient, provided sufficient data were available. This SUL or Guidance Level reflects the safe maximum amount of a micronutrient that will not cause any side effects when taken daily from all sources for a lifetime.
| The maximum safe daily intake for biotin is 1,000 µg. The maximum safe daily intake for biotin is 20 times the EU recommended daily intake (Nutrient Reference Value, NRV). |
This value applies to adults 19 years of age and older. It does not apply to pregnant women and nursing mothers due to insufficient data.
No adverse side effects have been reported for biotin, even after years of administration of high doses.
Sustained intake of biotin for therapeutic purposes at 200 times the NRV value did not result in any undesirable side effects. Also, in a study in diabetics, no adverse effects were observed after daily intake of 9,000 µg of biotin, taken for up to four years.
The safe daily maximum amount of biotin is far from being reached in the German population via the conventional diet and dietary supplements.
