Blood in Ejaculate (Hemospermia): Or something else? Differential Diagnosis

Congenital malformations, deformities, and chromosomal abnormalities (Q00-Q99).

  • Cysts of the glandulae seminales (seminal vesicles; congenital or acquired).

Blood, hematopoietic organs – immune system (D50-D90).

Endocrine, nutritional, and metabolic disorders (E00-E90).

Cardiovascular system (I00-I99).

Infectious and parasitic diseases (A00-B99).

  • Schistosomiasis – worm disease (tropical infectious disease) caused by trematodes (sucking worms) of the genus Schistosoma (couple flukes).
  • Tuberculosis (consumption) of the genitourinary system.
  • Other specific infections: Neisseria gonorrhoeae, Treponema pallidum, cytomegalovirus.

Liver, gallbladder, and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).

  • Severe liver disease, such as cirrhosis ( irreversible damage to the liver and a pronounced remodeling of liver tissue).

Neoplasms – tumor diseases (C00-D48).

  • Malignant neoplasm of the urogenital system, unspecified.
  • Urinary bladder carcinoma (bladder cancer).
  • Testicular carcinoma (testicular cancer)
  • Lymphoma / leukemia (blood cancer)
  • Prostate carcinoma (cancer of the prostate gland) (patients > 40 years).
  • Tumors of the small pelvis

Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99).

  • Bleeding of the vesicular glands (glandula vesiculosa, vesicula seminalis) and prostatic cysts.
  • Epididymitis (inflammation of the epididymis).
  • Urethral stricture – narrowing of the urethra.
  • Urinary tract infection, unspecified (commonly with Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, and Enterobacter).
  • Orchitis (testicular inflammation)
  • Pathological changes of the urethra/bladder and prostate:
  • Prostatitis (inflammation of the prostate gland) or prostatovesiculitis (inflammation of the prostate gland and seminal vesicle).
  • Spermatocystitis (seminal vesicle inflammation).
  • Urogenital tuberculosis
  • Urethritis posterior (urethritis concerning the posterior urethra).
  • Cysts of the glandulae seminales (congenital or acquired).

Injuries, poisoning, and other sequelae of external causes (S00-T98).

  • Injuries (not remembered/not recognized) are frequently present

Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99)

  • Idiopathic hemospermia (50-70% of cases); ie, no causes of hemospermia are found

Other causes

  • Iatrogenic (“caused by a physician”) – condition following surgical intervention on the genitourinary system (e.g., prostate puncture. shock wave lithotripsy); after prostate biopsy (removal of tissue from the prostate), more than 80 percent of men report hemospermia that lasts up to four weeks
  • Sexual deviations (deviant sexual behavior): traumatization, for example, of
    • Urethral injury due to too tight penile ring or insertion of foreign objects.
    • Prostate injury due to stimulator

Medication