The following are the most important diseases or complications that may be contributed to by brain tumors:
Cardiovascular system (I00-I99).
- Venous thromboembolism (VTE; occlusion of a blood vessel by a detached blood clot).
Neoplasms – tumor diseases (C00-D48).
- Hemorrhage into the tumor
Psyche – nervous system (F00-F99; G00-G99)
- Affective disorders (mood disorders)
- Attention-deficit/hyperactivity disorder (ADHD).
- Epilepsy (seizures)
- Cognitive disorders (memory disorders)
Prognostic factors
- Prognostic influencing factors for glioblastoma multiforme (GBM) are:
- Age <60 years
- Functional status: Karnofsky performance status ≥ 70
- EGFR gene: EGFR amplification less frequent.
- Isocitrate dehydrogenase gene: IDH1/2 mutation.
- MGMT gene promoter: positive methylation status.
- Tumor location: tumor-free subventricular zone; non-eloquent region.
- Tumor resection: “gross total resection”
- TMZ concomitant + adjuvant: TMZ response
- Chemotherapy with nitrosourea: radiochemotherapy (RCTX).
- Chemotherapy: Salvage chemotherapy
- Neurosurgical intervention: ≥ 2 surgeries.
- Radiotherapy: re-irradiation
Legend
- EGFR = “epidermal growth factor receptor”
- MGMT = O6-methylguanine-DNA methyltransferase.
- TMZ = temozolomide
