First-line therapy: antibiotic therapy, i.e., combination of doxycycline + aminoglycoside (e.g., streptomycin; see below); according to a Cochrane analysis, this combination is better than the 6-week administration of doxycycline + rifampicin
Alternatively, other aminoglycosides: e.g., gentamycin (5 mg/kg bw/day i.m. or i.v. for 10-14 days) + doxycycline (2 times 100 mg/day for 45 days)
Second-line therapy: antibiotic therapy with quinolones + rifampicin.
Due to high relapse rates (recurrence of the disease), monotherapies are contraindicated (“not allowed”).