Products
Carbetocin is commercially available as a solution for injection (Pabal, generic). It has been approved in many countries since 2008.
Structure and properties
Carbetocin (C45H69N11O12S, Mr = 988.2 g/mol) is a synthetic octapeptide analog of oxytocin.
Effects
Carbetocin (ATC H01BB03) is a rapid and long-acting oxytocin agonist. It binds to oxytocin receptors in uterine smooth muscle, increasing muscle tone and stimulating contractions. It thus prevents uterine atony and excessive bleeding. Unlike oxytocin, it does not need to be infused for several hours because it has a longer duration of action.
Indications
To prevent uterine atony after cesarean delivery under anesthesia.
Dosage
According to the SmPC. The drug is injected intravenously once. Administration is slow and immediately after cesarean delivery preferably before removal of the placenta.
Contraindications
For complete precautions, see the drug label.
Adverse effects
The most common possible adverse effects include low blood pressure, facial flushing, a feeling of warmth, itching, headache, tremor, nausea, and abdominal pain.
