Cardiovascular diseases and high-dose vitamin D
Various studies have already pointed to a connection between a reduced vitamin D status and an increased risk of cardiovascular disease. Possible connections exist between the Vitamin and illnesses like: Heart attack Stroke Heart weakness High blood pressure Heart rhythm disturbances Thrombosis For this reason, research has been carried out into how a monthly high dose of 200,000 i. E. affects the development of cardiovascular diseases. The results showed no significant difference between the vitamin D group and the control group.
In view of this, the researchers conclude that a monthly high dose does not really show any benefit in preventing the development of cardiovascular disease. However, they also admit that a weekly or even daily high dose still needs to be investigated in this respect. Similar results have been obtained by researchers with similar study designs in hypertension alone. Here, too, after a long-term administration of 100,000 i. E. per month over 1 1⁄2 years no significant improvement could be determined, if patients did not already have a Vitamin D deficiency before.
- Heart attack
- Stroke
- Heart failure
- High blood pressure
- Cardiac arrhythmias
- Thrombosis
Bone health and high-dose vitamin D
The aspect most commonly associated with vitamin D is bone health.This connection has also been repeatedly investigated in recent studies, including in the context of high-dose vitamin D. To date, the correlation between vitamin D supplementation and bone density in older people has not been sufficiently investigated, and some studies provide contradictory results. Researchers have also investigated this fact in 2019 and have supplied three different control groups with different amounts of vitamin D every month. After one year, no significant differences in bone density could be detected.
Ultimately, however, it was also found that a monthly intake of up to 48,000 i. E. Vitamin D can be considered safe, because none of the test persons showed any serious side effects. Potentially negative effects were found in another study with the same subject. There, three different control groups received either 400, 4,000 or 10,000 IU.
E. Vitamin D daily. In the higher-dose groups, even lower bone densities in the radius were measured after the end of the studies. The researchers conclude therefore that an increased Vitamin D administration does not have a positive influence on the bone density and that future studies would have to show whether more Vitamin D affects perhaps even negatively the bone density.
That however not all studies fail negatively, an investigation of the frailty of older persons shows. In this study older adults received up to 4. 000 i. E. daily and it could be stated that their physical efficiency (running speed, grip strength and other functions) improved thereby. However, these positive results could only be observed in those persons who had already been classified as frail at the beginning.
