Causes of psoriasis
Psoriasis is a disease with a hereditary disposition. The predisposition for it is therefore in our genes. Thus, an accumulation within the families is also noticeable.
The theory of heredity has been proven by twin studies. The increased occurrence in identical twins clearly speaks for the genetic component of psoriasis. However, inheritance cannot be fixed to one gene, but is inherited on several genes (polygenic inheritance).
Several external factors (for example environmental factors) also play a role (multifactorial inheritance). It is assumed that there is a so-called threshold value. This means that a certain threshold must be exceeded in order for the disease to break out.
It is assumed that psoriasis does not occur below this virtual threshold value. It has also been observed that the antigen HLA-1 and HLA-2, a typical genetic code (genetic fingerprint), is present in affected individuals. Certain environmental factors can cause and promote the manifestation (manifestation) of the disease in genetically predisposed individuals.
These include, among others: Relatively, experts also agree that an immunological overreaction is the trigger of psoriasis. This immune reaction is mediated by defense cells, so-called T-lymphocytes. Normally, the T-lymphocytes are directed against foreign material, e.g. bacteria and viruses.
In the case of psoriasis, the defence system is no longer able to distinguish between the body’s own and foreign components and thus causes the disease itself. The summer, climatic factors (sun and sea) and hormonal factors (pregnancy) have a positive influence on this disease.
- Infections (e.g.
streptococcus infection)
- Medication (e.g. beta-blockers, antirheumatic drugs)
- Psychological stress
- Alcoholism
- Increased nicotine consumption
- Stopping a cortisone therapy
Psoriasis vulgaris is the most common form of psoriasis and is characterized by its onset as a punctiform focal point that increases in size. The convergence of individual foci results in different forms. For example, a map-like form, one with a more ring-shaped appearance and a form that is winding. It is a chronic autoimmune disease that runs in waves.It can occur in virtually any part of the body, but is often found in typical locations. These include:
- Scalp (
