Berberine and sanguinarine are substances that can destroy DNA sequences and thus have antimicrobial and antiviral properties. Furthermore, most alkaloids can interact with receptors of the nervous system and other proteins, which is the reason for the antispasmodic, analgesic and anti-inflammatory properties of celandine.
According to experiments, the drug also stimulates bile formation and flow.
Celandine: side effects
Experimentally, a hepatoprotective, i.e., liver-protecting, effect and good clinical tolerability of celandine have been demonstrated in a high number of patients. In parallel, however, reports were made by the Drug Commission and the German medical profession postulating a link between the ingestion of celandine and liver damage.
These data were later considered questionable by other associations, but nevertheless only preparations with a very low alkaloid content (daily dose below 2.5 µg) are currently considered safe. Medicines with a daily dose of 2.5 µg to a maximum of 2.5 mg of alkaloids must contain appropriate information in the product information.
Currently, there are no known interactions with other agents.
