Cetylpyridinium Chloride

Products

Cetylpyridinium chloride is found in lozenges for sore throats (Angina MCC, Lidazone, Lysopain N, Mebucaine N, Neo-Angin, among others).

Structure and properties

Cetylpyridinium chloride or 1-hexadecylpyridinium cloride (C21H38ClN – H2O, Mr = 358.0 g/mol) is a quaternary ammonium base. It exists as a white powder that is soapy to the touch. The aqueous solution foams strongly when shaken.

Effects

Cetylpyridinium chloride (ATC D08AJ03) has antiseptic properties. It is a surface-active soap.

Indications

Cetylpyridinium chloride is used for local disinfection, mainly for inflammation of the mouth and throat, for halitosis, and usually in combination with other agents.

Contraindications

  • Hypersensitivity
  • Mucosal damage (delayed wound healing)

Full precautions can be found in the drug label.

Interactions

Effects are reduced by anionic soaps, such as those found in toothpaste. Quaternary ammonium compounds are inactivated by protein, serum, pus, phospholipids, and lipid-containing substances.

Adverse effects

Possible adverse effects include allergic reactions, sensitization, delay in wound healing, and discoloration of the tongue or teeth.