Chondrosarcoma: Drug Therapy

Therapeutic targets

  • Relief of pain
  • Stabilization of bone sections at risk of fracture
  • Removal of the tumor – see “Surgical Therapy“.
  • Healing

Therapy recommendations

Chondrosarcoma responds poorly to chemotherapy and radiatio (radiation therapy), making surgical removal the only and most effective treatment option.

  • Analgesia according to WHO staging scheme:
    • Non-opioid analgesic (paracetamol, first-line agent).
    • Low-potency opioid analgesic (e.g., tramadol) + non-opioid analgesic.
    • High-potency opioid analgesic (eg, morphine) + non-opioid analgesic.
  • Indications for chemotherapy – palliative (without curative approach):
    • Metastatic highly malignant (very malignant) chondrosarcoma.
    • Dedifferentiated chondrosarcoma
    • Mesenchymal chondrosarcoma