Diseases that can lead to chronic pain include:
Endocrine, nutritional, and metabolic diseases (E00-E90).
- Fabry disease (synonyms: Fabry disease or Fabry-Anderson disease) – X-linked lysosomal storage disease due to a defect in the gene encoding the enzyme alpha-galactosidase A, resulting in progressive accumulation of the sphingolipid globotriaosylceramide in cells; mean age of manifestation: 3-10 years; early symptoms: Intermittent burning pain, decreased or absent sweat production, and gastrointestinal problems; if left untreated, progressive nephropathy (kidney disease) with proteinuria (increased excretion of protein in urine) and progressive renal failure (kidney weakness) and hypertrophic cardiomyopathy (HCM; disease of the heart muscle characterized by thickening of the heart muscle walls). Warning signs (red flags) that indicate Fabry disease:
- Pain crises?
- Pain in hands and feet of burning character?
- Pain peripherally intensified (hands and feet) and of high intensity?
- Pattern of spread of pain from distal to central?
- Sweat secretion decreased and not adapted to physical exertion?
- Trigger: heat or cold, exertion from exercise, stress or fever?
- Family members with similar complaints?
Factors influencing health status and leading to health care utilization (Z00-Z99).
- Chronic stress
- Bullying
Musculoskeletal system and connective tissue (M00-M99)
- Arthritis (inflammatory joint disease).
- Osteoarthritis
- Fibromyalgia (fibromyalgia syndrome) – syndrome that can lead to chronic pain (at least 3 months) in several regions of the body.
- Rheumatological diseases
Neoplasms – tumor diseases (C00-D48)
Psyche – nervous system (F00-F99; G00-G99).
- Anxiety disorders
- Depression
- Diabetic neuropathy – chronic disorders of peripheral nerves or parts of nerves caused by diabetes mellitus (diabetes).
- Mental disorders, without further specification
- Somatic symptom disorder (SSD) associated with pain.
Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99)
- Pain, unspecified
Injuries, poisonings, and other consequences of external causes (S00-T98)
- Fractures (bone fractures; hip and vertebral fractures) → Chronic pain in multiple body regions (“chronic widespread pain,” CWP): pain that persists for more than three months and affects the axial skeleton, the right and left sides of the body, and regions above and below the waist:
- Vertebral fractures: 2.7-fold increase in CWP in men, 2.1-fold increase in women
- Hip fractures in women: 2.2-fold CWP increase.
- Trauma (injury), unspecified
Other
- Athletes – especially in competitive sports
