Products
Cimetidine was commercially available in the form of film-coated tablets (Tagamet). Currently, there are no longer any human medicines registered with the active ingredient in many countries. Cimetidine was developed in the 1960s and 1970s under the leadership of Sir James Black as the first wirsktoff from the group of H2 receptor antagonists and came on the market in the 1970s. Cimetidine quickly became a blockbuster.
Structure and properties
Cimetidine (C10H16N6S, Mr = 252.3 g/mol) is an imidazole and guanidine derivative. It exists as a white powder that is sparingly soluble in water.
Effects
Cimetidine (ATC A02BA01) inhibits the secretion of gastric acid and pepsin in the stomach. Effects are due to selective antagonism at histamine H2 receptors.
Indications
- Gastric and intestinal ulcers, for prevention and treatment.
- Gastroesophageal reflux disease
- Zollinger-Ellison syndrome
Dosage
According to the professional information. The tablets are taken with food.
Contraindications
- Hypersensitivity
- Impaired kidney function
- Children and adolescents in growth
For complete precautions, see the drug label.
Interactions
Cimetidine is an inhibitor of several CYP450 isozymes and therefore has a high potential for interaction. Other drug-drug interactions are possible due to the elevation of gastric pH.
Adverse effects
The most common potential adverse effects include bradycardia, tachycardia, conduction abnormalities, and rash.
