Collagen-I telopeptide is a marker of bone resorption and thus of osteoclast (bone resorption cell) activity. Collagen-I telopeptide is not bone-specific, as it is also found in other organs such as skin and cartilage. It is subject to wide diagnostic variations.
Collagen I telopeptide is never the 1st choice laboratory parameter for the above reasons. Deoxypyridinoline (DPD), a bone-specific marker, should also always be measured.
The procedure
Material needed
- Urine
Preparation of the patient
- Not necessary
Disruptive factors
- None known
Standard values
Each laboratory has its own standard ranges for this purpose!
Indications
- Suspected bone metabolism disorders with increased bone resorption.
- Therapy control in bone metabolism disorders with increased bone resorption.
Interpretation
Interpretation of increased values
- Immobilization
- Bone metastases
- Plasmocytoma (multiple myeloma) – disease caused by malignant (malignant) proliferation of special blood cells (plasma cells).
- Postmenopausal bone loss – after menopause.
- Osteoporosis with increased bone turnover
- Rheumatoid arthritis
Interpretation of decreased values
- Not relevant
Other notes
- Collagen I telopeptide is never the 1st choice laboratory parameter. Deoxypyridinoline (DPD) should also always be measured
