Conn Syndrome: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90).

  • Adrenogenital syndrome (AGS)-autosomal recessive inherited metabolic disorder characterized by disorders of hormone synthesis in the adrenal cortex; these disorders result in deficiencies of aldosterone and cortisol; virilization (masculinization) in girls and pubertas praecox (premature sexual development) in boys, respectively.
  • Bilateral adrenal hyperplasia – overdevelopment of the adrenal glands (bilateral).
  • Glucocorticoid-suppressible hyperaldosteronism (GSH; monogenic hypertension) – familial form of hyperaldosteronism (autosomal dominant); the disease is characterized by arterial hypertension at adolescent age, aldosterone levels are markedly elevated. Blood pressure cannot be normalized by the commonly used antihypertensives (blood pressure lowering drugs) such as ACE inhibitors or beta blockers, but can be lowered by taking dexamethasone
  • Pseudohyperaldosteronism due to abusus of licorice.
  • Secondary hyperaldosteronism – hyperaldosteronism occurring due to other diseases.

Cardiovascular system (I00-I99)

  • Essential hypertension – form of hypertension in which the cause is unknown.
  • Low-renin essential hypertension – form of hypertension characterized by a decreased occurrence of renin.
  • Renal artery stenosis – narrowing of the renal artery; leads to the so-called renovascular hypertension.

Neoplasms – tumor diseases (C00-D48).

  • Aldosterone-producing carcinoma – malignant neoplasm; very rare.

Drugs

  • Diuretics (dehydrating medications) – can lead to hypokalemic hypertension when combined with existing hypertension.