Contraindication
Methotrexane should not be taken at:
- Liver damage
- Renal dysfunction
- Known allergy to Methotrexate
- Diseases of the haematopoietic system
- Infections
- Increased alcohol consumption
- Ulcers in the gastrointestinal tract
Interaction
Increased toxicity to methotrexate has been observed in the presence of folic acid deficiency or simultaneous intake of drugs that cause folic acid deficiency (e.g. sulfonamides, trimethoprim-sulfamethoxazole). Taking methotrexate and alcohol at the same time should be avoided. If other liver-damaging drugs (e.g. retinoids, sulfasalazine, leflunomide, Azathioprine®) are taken at the same time, regular monitoring by a physician should be performed.
The same applies to concomitant use of sulfonamides, trimethoprim-sulfamethoxazole, chloramphenicol, pyrimethamine.No vaccination with live vaccine drops is recommended while taking Methotrexate. An indirect increase in dose may be caused by medication.
- Penicillin (antibiotic)
- Salicylates (Aspirin)
- Phenytoin
- Barbiturates
- Tranquilizers (sedatives)
- Oral contraceptives
- Tetracycline (antibiotic)
- Amidopyrin derivatives
- Sulfonamides and p-Aminobenzoic acid
- P-Aminohippuric acid
- Probenecid
