Contraindications | Amlodipine

Contraindications

Amlodipine should only be given with special caution to patients with a narrowing of the aortic valve (see aortic valve stenosis), as the drug’s blood pressure-lowering effect can lead to reduced blood flow to the heart, which in turn could trigger a heart attack. In patients with a damaged liver, a lower starting dose (2.5 mg or less) should be selected when starting therapy with amlodipine, because amlodipine is processed in the liver and, if the liver is damaged, it remains in the blood for longer at a higher dose and thus remains functional, so that the blood pressure may be lowered too much even though the correct dose has been taken. Amlodipine has been shown in animal experiments to be harmful to the unborn baby. Since there are understandably no comparable studies in humans, the use of amlodipine during pregnancy is generally not recommended. No studies have been conducted on side effects during breastfeeding, so it is not recommended that amlodipine be taken during the breastfeeding period.

Combination and interaction with other substances

Amlodipine is often combined with beta-blockers in the basic therapy, as both groups of drugs together can better lower blood pressure. When it comes to nutrition, one must pay particular attention to the consumption of grapefruit or grapefruit juice, as this can slightly increase the concentration of amlodipine in the blood. In addition, one should pay special attention to foods, especially herbs, which either lower or raise blood pressure, as their consumption can derail the correctly adjusted blood pressure.

If you are particularly susceptible to these foods, it is recommended that you seek nutritional advice from a trained nutritionist. Amlodipine can interact with many common drugs, very often the amount in the blood and thus the effect of one of the two drugs is altered. Some of the commonly used medications with which amlodipine interacts are Therefore, it is very important to inform the treating physician about the current list of drugs before prescribing amlodipine. – Barbiturates

  • Beta blocker
  • Clopidogrel
  • Cyclosporine
  • Macrolides
  • MAO – Inhibitors
  • Melatonin
  • Phenytoin
  • Simvastatin.

Amlodipine and alcohol – is that compatible?

Amlodipine causes the blood vessels to dilate and thus lowers blood pressure. Alcohol can have the same effect. If both are consumed at the same time, blood pressure can be lowered considerably.

This can increase the side effects of amlodipine. Dizziness, circulatory instability and even life-threatening cardiovascular problems can be triggered. It is advised to avoid alcohol if possible when taking amlodipine.

Side effect Impotence

Whether antihypertensive drugs such as amlodipine lead to impotence is controversially discussed. Different studies show different results. On the one hand, a connection between erectile dysfunction and diseased, constricted vessels is more likely to be suspected, for example in people with diabetes mellitus, overweight or smokers.

Vasodilatation by antihypertensive drugs such as amlodipine did not show a direct connection between taking the drug and impotence in some studies. On the other hand, slightly more erectile dysfunction could be detected when taking beta-blockers. Since amlodipine is often administered in combination with beta-blockers, the side effect of impotence cannot be completely ruled out.

Furthermore, the reason could possibly be the biochemical structure of amlodipine. Since it is a modification of the so-called nifedipine. Because nifedipine causes an increase in cholesterol in the sperm.

The cholesterol is deposited on the sperm membrane and thus prevents the receptors from protruding from this membrane. This prevents them from attaching to the egg cell. This leads to inability to conceive. If nifedipine was discontinued, fertility was restored after three months. Whether this mechanism is similar in the case of amlodipine is not certain.