Contraindications

If there is a known allergy or hypersensitivity to the active ingredient dexamethasone, Lipotalon® must not be used. Other components of the Lipotalon® injection solution are soybean oil, glycerol and phospholipids from egg yolk. If treatment with Lipotalon® is to be carried out, there must be no allergy to these substances either.

Another very important contraindication is the bacterial inflammation of the respective joint. Since Lipotalon® causes a reduced inflammatory and, above all, defensive reaction, the body’s own defense mechanisms can no longer be effective. As a result, the bacteria continue to multiply and the inflammation spreads further.

Treatment is also not advisable if there is a skin infection in the vicinity of the joint or if the patient is affected by a severe general infection. Lipotalon® should also be avoided in cases of increased bleeding tendency, unstable joint conditions and joint effusions. In diabetics, a close blood glucose control must be performed after administration of Lipotalon®.

Since dexamethasone, like all glucocorticoids, causes an increase in blood sugar levels, the doses of medication and insulin may need to be adjusted. Special caution should also be exercised in patients with (difficult-to-adjust) high blood pressure, as the use of any cortisone preparation can cause an increase in blood pressure. Lipotalon® should not be used in patients with non-activated and non-inflammatory arthrosis.

If complaints and joint effusions occur repeatedly despite repeated treatment, no further applications should follow. Whether the use of Lipotalon® during pregnancy can harm the unborn child has not been proven. However, the application should be viewed critically, since the active ingredient dexamethasone can cause child damage, especially at the beginning of pregnancy.

In the last third of the pregnancy, the elevated dexamethasone level in the blood can cause adrenal hypofunction in the child. Lipotalon® should not be used in children due to a lack of clinical experience. The use in athletes is to be viewed critically, as the WADA Prohibited List lists glucocorticoids and prohibits, among other things, intramuscular administration.

In general, Liptalon® should be used with caution during pregnancy. Although this is a local injection, the active ingredient can be absorbed into the blood. Lipotalon® is placenta-compatible.

Especially in the first weeks, when the organ systems are formed, it cannot be excluded that Lipotalon® could damage the fetus. In the last weeks of pregnancy, the production of the child’s own hormones may be reduced, which must then be substituted (administered) after birth. Nevertheless, pregnancy is not a complete contraindication for the administration of Lipotalon®. The risks that exist during pregnancy should be discussed thoroughly with the gynecologist prior to the injection.