Clinically apparent copper deficiency is relatively uncommon. Serum copper and its storage form with coeruloplasmin a transport protein can drop to 30% of normal levels before clinical symptoms develop. One of the most common clinical signs of copper deficiency is anemia (anemia) and all the associated symptoms of pallor and fatigue. This form of anemia does not respond to iron therapy, but is correctable by the addition of copper. It is assumed that in this case the iron transport is disturbed due to a low concentration of coeruloplasmin. Copper deficiency can also disrupt the function of leukocytes (white blood cells) and cause what is known as neutropenia. This causes affected individuals to be more susceptible to infections. Osteoporosis and other abnormalities of bone development due to copper deficiency have occurred in infants and young children.
Less common hallmarks of copper deficiency may include pigmentation disorders, neurological symptoms, and growth disturbances.
