For the most part, the infection is asymptomatic (60%), meaning that it causes no symptoms at all. When symptoms do occur, they are usually very nonspecific.
The following symptoms and complaints may indicate Coxsackie A infection:
- Bronchitis
- Cephalgia (headache)
- Diabetes mellitus type 1
- Exanthem (rash) – patchy rash associated with papule (vesicle) formation.
- Fever
- Hand-foot-mouth disease (HFMD; hand-foot-mouth exanthema) [virus types A2 – A8, A10, A12, A14, A16]
- Herpangina – vesicles on the palate.
- Conjunctivitis, acute hemorrhagic (conjunctivitis) [virus type A24]
- Laryngitis (inflammation of the larynx).
- Myalgia (muscle pain)/limb pain
- Myocarditis (inflammation of the heart muscle)
- Otitis media (inflammation of the middle ear)
- Pharyngitis, acute lymphonodular (pharyngitis).
- Pericarditis (inflammation of the pericardium)
- Pseudoparalysis (paralysis) [virus type A7]
- Rhinitis (rhinitis) [virus type A21]
- Nausea (nausea)/vomiting
- Uncharacteristic febrile illness (“summer flu“).
The following symptoms and complaints may indicate Coxsackie B infection:
- Cephalgia (headache)
- Diabetes mellitus type 1 (?)
- Encephalitis (inflammation of the brain)
- Fever
- Meningitis, aseptic (meningitis).
- Myocarditis (inflammation of the heart muscle)
- Pericarditis (inflammation of the pericardium)
- Pleurodynia (Bornholm disease) – stabbing pain in the thorax (chest)/upper abdomen and also muscle pain (myalgia acuta epidemica), joint pain and pseudoappendicitis accompanied by sweating
- Respiratory diseases
- Severe, systemic disease in neonates (meningoencephalitis/combined inflammation of the brain (encephalitis) and meninges (meningitis), myocarditis/heart muscle inflammation).
- Uncharacteristic, febrile illness (“summer flu“).
