Creutzfeldt-Jakob Disease: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90).

  • Hashimoto’s encephalopathy – form of brain abnormality caused by thyroid hormones.
  • Neuronal ceroid lipofuscinoses (NCL or CLN) – group of rare, autosomal recessive inherited metabolic diseases of childhood that causes seizures, movement disorders, and other neurological disorders.

Cardiovascular System (I00-I99).

  • Vasculitis (vascular inflammation)

Infectious and parasitic diseases (A00-B99).

  • HIV infection
  • Rubella/herpes encephalitisinflammation of the brain caused by rubella/herpes infection.
  • Subacute sclerosing panencephalitis (SSPE) – late complication after measles infection, which entails a generalized inflammation of the brain with nerve demyelination (demyelination) and severe damage and always ends lethally (fatal)
  • Syphilis (Lues)
  • Rabies (Rabies)

Liver, gallbladder and bile ducts – Pancreas (pancreas) (K70-K77; K80-K87).

Neoplasms – tumor diseases (C00-D48).

  • Brain tumors, unspecified
  • Paraneoplastic – as an accompanying symptom in neoplasms (malignant neoplasms).

Psyche – nervous system (F00-F99; G00-G99)

  • Alcoholism
  • Delir
  • Dementias of all kinds
  • Encephalitis (inflammation of the brain)
  • GAD antibody encephalitis (GAD encephalitis; GAD = glutamate decarboxylase).
  • Epilepsy
  • Alzheimer’s disease
  • Parkinson’s disease
  • Multisystem atrophy – degenerative neurological disease similar to Parkinson’s disease, but much more severe and rapid.
  • Normal pressure hydrocephalus – “hydrocephalus”, which does not lead to an increase in pressure due to a simultaneous decrease in brain tissue.
  • Progressive multifocal leukoencephalopathy – demyelinating disease of the brain.
  • Progressive myoclonic epilepsy – progressive form of epilepsy.
  • Psychiatric disorders
  • Schizophrenia (mental illness with a loss of reality).

Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99).

  • Hypothermia (hypothermia)
  • Uremia (occurrence of urinary substances in the blood above normal values).

Environmental stress – intoxications (poisoning).

  • Bismuth intoxication (bismuth poisoning).
  • Lithium intoxication (lithium poisoning)