Products
Cromoglicic acid has been approved for food allergy in many countries since 1982 and is available in capsule form (Nalcrom).
Structure and properties
The drugs contain sodium cromoglicate (C23H14Na2O11, Mr = 512.3 g/mol), a white, crystalline, hygroscopic powder that is soluble in water. It is the disodium salt of cromoglicic acid.
Effects
Sodium cromoglicate (ATC A07EB0) is mast cell stabilizing. It inhibits the release of various inflammatory mediators from mast cells in the digestive tract. These include histamine, kinins, ECF, NCF, prostaglandins, and leukotrienes. Sodium cromoglicate acts locally in the intestine because it has very low bioavailability and is only 1-2% absorbed.
Indications
Preventive treatment for locally and systemically manifested food allergies.
Dosage
According to the professional information. Medicines are taken four times a day, 15-30 minutes before meals each time.
Contraindications
The medicines are contraindicated in case of hypersensitivity. For complete precautions, see the drug label.
Interactions
No interactions with other drugs are known to date.
Adverse effects
Occasionally, headache, indigestion, skin rashes, andjoint pain have been reported.
