Products
Cromoglicic acid nasal spray has been approved in many countries since 1975. Generic products are commercially available (e.g., Cromodyn). The original Lomusol has been off the market since 2014.
Structure and properties
The spray contains sodium cromoglicate (C23H14Na2O11, Mr = 512.3 g/mol), a white, crystalline, hygroscopic powder that is soluble in water. It is the disodium salt of cromoglicic acid.
Effects
Sodium cromoglicate (ATC R01AC01) has mast cell stabilizing properties. It inhibits the release of various inflammatory mediators from mast cells that play an important role in the allergic response. These include histamine, kinins, ECF, NCF, prostaglandins and leukotrienes. The effects occur with a delay within about two weeks.
Indications
For preventive treatment of hay fever and perennial allergic rhinitis.
Dosage
According to the expert information. The spray must be administered frequently: 1 spray is given into each nostril four times daily. It is important to use the spray preventively and not only for symptomatic treatment.
Contraindications
The spray is contraindicated in case of hypersensitivity. Refer to the drug label for complete precautions.
Interactions
No interactions with other drugs are known to date.
Adverse effects
The most common possible adverse effects include irritation of the nose. Occasionally, headache and transient taste disturbances may occur. Very rarely, allergic reactions have been reported.
