Cyclophosphamide

Products

Cyclophosphamide is commercially available in the form of dragées and as a dry substance for intravenous infusion (Endoxan). It has been approved in many countries since 1960.

Structure and properties

Cyclophosphamide (C₇H₁₅Cl₂N₂O₂P, M_r = 261.1 g/mol) is a cytostatic drug belonging to the group of oxazaphosphorines, nitrogen-lost derivative.

Effects

Cyclophosphamide (ATC L01AA01) has cytotoxic properties. The effect is due to an interaction of its alkylating metabolites with DNA, resulting in strand breaks and cross-linking of DNA strands or DNA-protein cross-links. In the cell cycle, a slowing of the passage through the G2 phase is caused. The cytotoxic effect is not cell cycle phase specific but is cell cycle specific.

Indications

• Tumor therapy
• Autoimmune diseases, rheumatoid arthritis
• Immunosuppressive treatment in organ and bone marrow transplantation.