ExplanationDefinition
Zyprexa® belongs to the group of atypical neuroleptics. In addition to a good antipsychotic effect, which is particularly used in the therapy of mania, it has a relatively small spectrum of side effects. Zyprexa®, Zyprexa® Velo Tabs
Chemical name
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine Chemical formula: C17H20N4S6-21⁄2H2O
Active ingredient
OlanzapineZyprexa® is used as a drug therapy for various psychiatric disorders. Fields of application are:
- Schizophrenia
- Mania
- Bipolar disorders (prophylaxis)
- Borderline fault
- Delusional Depression
Dosage form
- TabletsFilm coated tablets
- Ampoules
Effect
Antipsychotics are drugs that focus on the treatment of psychotic symptoms. The main mechanism lies in the reduction of the activity of the messenger substance dopamine in the brain. For those interested: Olanzapine is primarily used to block 5-HT2, D1-5 and mACh receptors. Tablets are available in dosages of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg and 20 mg. Enamel tablets are available in dosages of 5 mg, 10 mg, 15 mg and 20 mg. Ampoules are available in the dosage 10 mg
Side effect
Only very common (>10%) to common (1-10%) side effects are listed; occasional, rare or very rare side effects are not listed!
- Increase in appetite with weight gain (overweight) is the most common NW. However, weight gain is usually limited and usually does not lead to overweight.
- Increase of the blood sugar level (diabetes mellitus)
- Swindle
- Dry mouth
- Constipation (constipation)
- Temporary increase of liver values (transaminases)
- Rarely: Extrapyramidal disordersMore information about this side effect can be found in our topic Extrapyramidal Syndromes
- Rarely: Leukopenia (decrease in white blood cells)
- Rarely: Thrombocytopenia (drop in blood platelets)
Interaction
The degradation of the drug is accelerated both by smoking and by taking carbamazepine at the same time. Fluvoxamine can slow down the breakdown of the drug.
