1st order
- Gonadectomy (removal of the gonads) may be required An intermediate-risk gonadal degeneration is present in:
- Ullrich-Turner syndrome (UTS) with Y-linked components.
- 17β-HSD (17b-hydroxysteroid dehydrogenase).
- Gonadal dysgenesis (maldevelopment of the gonads).
- Partial androgen insensitivity syndrome (PAIS) with scrotal gonadal location (location of the testis in the scrotum).