Detomidine

Products

Detomidine is commercially available as a solution for injection and a gel (Domosedan, Equisedan, Medesedan). It has been approved in many countries since 1990.

Structure and properties

Detomidine (C12H14N2, Mr = 186.3 g/mol) is an imidazole derivative. It is structurally closely related to medetomidine.

Effects

Detomidine (ATCvet QN05CM90) is sedative, analgesic, and muscle relaxant. Its properties are due to agonism at α2-receptors.

Indications

Detomidine is used in horses and cattle for sedation and analgesia during examinations, treatments, and transport. An anatonist such as atipamezole may be used to abolish its effects.