Dimetindenmaleate

Products

Dimetinden maleate is commercially available as drops, gel, lotion, nasal spray, and nasal drops (Fenistil, Feniallerg, Vibrocil, Otriduo). The nasal products also contain the vasoconstrictor phenylephrine. The Fenistil products used internally (systemically) were renamed Feniallerg in 2009. The capsules and dragées are no longer available.

Structure and properties

Dimetind (C₂₀H₂₄N₂, M_r = 292.4 g/mol) is present in drugs as dimetindene maleate, a white crystalline powder that is poorly soluble in water. The name is derived from the two methyl groups on the sting and the central indene ring.

Effects

Dimetinden maleate (ATC D04AA13, ATC R06AB03) has antihistamine, antiallergic, antipruritic, depressant, and local anesthetic properties. The effects are due to antagonism at histamine H1 receptors.

Indications

External:

• See under dimetinden maleate gel

Internal:

• Allergy: Allergic rhinitis, urticaria.
• Itching
• Eczema

See under dimetinden maleate drops.