Diphtheria Postexposure Prophylaxis (PEP)

Postexposure prophylaxis is the provision of medication to prevent disease in persons who are not protected against a particular disease by vaccination but who have been exposed to it.

Indications (areas of application)

  • Persons with close (“face to face”) contact with a diseased person.
  • Epidemics or regionally increased morbidity (disease incidence).

Implementation

  • In persons with close (“face to face”) contact with a diseased person:
    • Chemoprophylaxis – regardless of vaccination status, preventive (prophylactic) antibiotic therapy: penicillin or erythromycin seven to ten days.
    • Postexposure vaccination, if the last vaccination 5 years ago.
  • At the first appearance of symptoms of diphtheria, the diphtheria antitoxin is administered immediately (= passive immunization).
  • In epidemics or regionally increased morbidity.
    • Vaccination according to the recommendations of the health authorities