Products
Medicines containing dithranol are no longer on the market in many countries. They can be imported from abroad or prepared as extemporaneous preparations in a pharmacy. Corresponding regulations can be found, for example, in the DMS. Dithranol is incorporated into petrolatum and thick kerosene, for example.
Structure
Dithranol (C14H10O3, Mr = 226.2 g/mol) is a photosensitive, yellow to brownish, crystalline powder that is practically insoluble in water. The substance dissolves in dilute alkali hydroxide solutions. It is a synthetic anthracene derivative.
Effects
Dithranol (ATC D05AC01) has antiproliferative, cytostatic, and anti-inflammatory properties.
Indications
For the treatment of psoriasis.
Contraindications
For complete precautions, see the drug label. Dithranol is irritating and should only come into contact with the area being treated. Carefully follow the directions in the package insert.
Adverse effects
Possible adverse effects include discoloration of the skin and clothing and local skin irritation such as redness and burning. Allergic and contact allergic reactions are rare.
