Double Vision, Diplopia: Or something else? Differential Diagnosis

Conditions that can cause binocular double vision:

Eyes and eye appendages (H00-H59).

  • Cataract (cataract)
  • Keratoglobus – spherical protrusion of the cornea.
  • Keratoconus – progressive, cone-shaped deformation of the cornea of the eye.
  • Lens (sub-)luxation – displacement of the lens.
  • Normosensory late strabismus – usually acute form of strabismus occurring between the third and seventh year of life.
  • Orbitaphlegmone – diffuse inflammation of connective tissue in the area of the eye socket.
  • Pseudoparalysis of the eye muscles
  • Pterygium conjunctivae (from Greek pteryx “wing” and Latin coniungere “to join”) – vascular tissue proliferation of the conjunctiva, which spreads to the cornea.
  • Strabismus (strabismus)

Endocrine, nutritional, and metabolic diseases (E00-E90).

Cardiovascular system (I00-I99).

  • Aneurysm of cerebral vessels – bulging of the wall of cerebral vessels.
  • Apoplexy (stroke)
  • Extracranial carotid stenosis – narrowing of the carotid artery outside the bony skull (extracranial).
  • Intracranial hemorrhage (bleeding within the skull; parenchymal, subarachnoid, sub- and epidural, and supra- and infratentorial hemorrhage)/intracerebral hemorrhage (ICB; cerebral hemorrhage)
  • Sinus cavernosus thrombosis – occurrence of blood clots (thrombosis) in the large collecting veins of the brain (venous sinus).

Infectious and parasitic diseases (A00-B99).

  • Botulism – poisoning with paralytic symptoms caused by botulinum toxin.
  • Syphilis (lues; venereal disease).
  • Trichinae (trichinellosis) – infectious disease caused by the parasites of the species Trichinella (nematodes/threadworms).

Musculoskeletal system and connective tissue (M00-M99).

Neoplasms – tumor diseases (C00-D48).

  • Brain tumors, unspecified

Psyche – nervous system (F00-F99; G00-G99).

  • Encephalitis (inflammation of the brain).
  • Guillain-Barré syndrome (GBS; synonyms: Idiopathic polyradiculoneuritis, Landry-Guillain-Barré-Strohl syndrome); two courses: acute inflammatory demyelinating polyneuropathy or chronic inflammatory demyelinating polyneuropathy (disease of the peripheral nervous system); idiopathic polyneuritis (diseases of multiple nerves) of spinal nerve roots and peripheral nerves with ascending paralysis and pain; usually occurs after infections.
  • Brain abscess (encapsulated inflammation of the brain), unspecified.
  • Pituitary exophthalmos – protrusion of the eyeballs caused by changes in the pituitary gland.
  • Meningitis (meningitis).
  • Migraine
  • Multiple sclerosis (MS)
  • Myasthenia gravis (MG; synonyms: myasthenia gravis pseudoparalytica; MG); rare neurological autoimmune disease in which specific antibodies against the acetylcholine receptors are present, with characteristic symptoms such as an abnormal load-dependent and painless muscle weakness, an asymmetry, in addition to the local also a temporal variability (fluctuation) in the course of hours, days or Weeks, an improvement after recovery or rest periods; clinically can be differentiated a purely ocular (“concerning the eye”), a faciopharyngeal (face (Facies) and pharynx (pharynx) concerning) emphasized and a generalized myasthenia; about 10% of cases already show a manifestation in childhood.
  • Neuropathy (nerve damage), unspecified.
  • Ophthalmoplegic migraine – form of migraine in which eye muscle paralysis occurs.
  • Progressive supranuclear gaze palsy (PSP; synonym: Steele-Richardson-Olszewski syndrome (SRO)) – neurodegenerative disease of unknown etiology associated with progressive cell destruction in the basal ganglia; leading symptom: progressive paresis (paralysis) of the eye muscles associated with a Parkinson’s-like symptom picture.
  • Pseudoparalysis of the eye muscles – for example, in the context of endocrine orbitopathy (inflammatory disease of the orbit, which in most cases occurs together with hyperthyroidism) or orbital fracture (bone fracture of the orbital wall)
  • Tolosa-Hunt syndrome (orbital apex syndrome, ophthalmoplegia dolorosa) – painful paralysis of the eye muscles resulting from damage to the cranial nerves that pass through the cavernous sinus
  • Transient ischemic attack (TIA) – sudden disturbance of blood flow to the brain, leading to neurological disorders that regress within 24 hours

Injuries, poisonings and other consequences of external causes (S00-T98).

  • Facial skull injuries, unspecified
  • Head injuries, unspecified
  • Orbital floor fracturebone fracture of the orbital wall.
  • Traumatic brain injury (TBI)

More

  • Double images can also occur physiologically (e.g., due toperception of objects closer than the fixed point).
  • Condition after surgical procedures on the eye

Medication

Environmental pollution – intoxications (poisonings).

  • Alcohol

Diseases that can cause monocular double vision:

Respiratory system (J00-J99).

  • Maxillary sinus mucocele (accumulation of mucus in the maxillary sinus); symptomatology: feeling of pressure in the orbit (bony eye socket) and swelling in the cheek and lower eyelid area

Eyes and eye appendages (H00-H59).

  • Early cataract (cataract)
  • Corneal changes, especially in the condition after inflammation or due to trauma.

Injuries, poisoning and other consequences of external causes (S00-T98).

  • Injuries to the cornea (cornea)

More

  • Double images can also occur physiologically (e.g., due toperception of objects closer than the fixed point).
  • Condition after surgical procedures on the eye