Early Summer Meningoencephalitis: Drug Therapy

Therapeutic targets

  • Relief of symptoms
  • Prevention of secondary diseases

Therapy recommendations

  • There is no causal therapy for TBE!
  • Symptomatic therapy (a causal antiviral therapy (drugs against the causative virus) does not exist).
    • Analgesics/pain relievers for headache (acetaminophen or metamizole)/antipyretics (antipyretic medications) or antiphlogistics (anti-inflammatory medications; diclofenac or ibuprofen)
    • Antiemetics (drugs against nausea and vomiting).
    • Antiepileptic drugs for seizures
  • Intensive care treatment required in approximately 5% of patients due torespiratory paralysis.
  • Postexposure prophylaxis (PEP) [see below].
  • See also under “Further therapy“.

Postexposure prophylaxis (PEP)

Post-exposure prophylaxis is the provision of medication to prevent disease in individuals who are not protected against a particular disease by vaccination but have been exposed to it.

Implementation

  • Even with early administration of hyperimmunoglobulin (antibodies to the virus) for the purpose of passive immunization, complete protection occurs in only about 60%.
  • Since it can come to severe courses in children even under post-exposure prophylaxis, passive immunization is contraindicated in children under 14 years (ie, there is a contraindication for this).