Eosinophilic Granulomatosis with Polyangiitis: Symptoms, Complaints, Signs

The following symptoms and complaints may indicate eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome (CSS):

Renal involvement is rare.

The disease typically occurs with a tricyclic course:

  • Prodromal stage (early phase of disease in which there are nonspecific symptoms; onset 2nd or 3rd decade of life:
    • Allergic symptomatology such as allergic asthma (in 70% of cases) [difficult to adjust], allergic rhinitis; furthermore, recurrent sinusitis (sinusitis) and polyposis nasi (benign mucosal growths that develop in the sinuses).
  • Eosinophil stage
  • Vasculitis stage (approximately 10 years after the onset of prodromal symptoms).
    • Generalization of symptoms in the sense of systemic vasculitis (inflammatory rheumatic diseases characterized by a tendency to inflammation of the (mostly) arterial blood vessels)