Eosinophilic Granulomatosis with Polyangiitis: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests.

  • Blood count – eosinophilia [increase in the number of eosinophilic granulocytes, in blood and affected organs].
  • Inflammatory parameters – CRP (C-reactive protein).
  • Total IgE [↑]
  • Alkaline phosphatase (AP) [possibly ↑]
  • Autoimmune serology:
    • PANCA (perinuclear antineutrophil cytoplasmic antibodies) (in only 40% of cases)Note: Histological confirmation of the diagnosis by biopsy of clinically affected organs should be sought.
  • Myeloperoxidase specificity [often.]