Epigallocatechin Gallate: Safety Assessment

Scientists published an intake NOAEL (No Observed Adverse Effect Level) in which no adverse effects were observed from the intake of epigallocatechin gallate (EGCG).

They identified a NOAEL of 600 mg daily of epigallocatechin gallate.In addition, they made a recommendation to establish a tolerable upper intake level (UL). Taking into account 100-fold safety factor, this value is 300 mg EGCG per day.

The value of the recommended UL is based on evidence from human intervention studies with healthy participants.

In 2018, the European Food Safety Authority (EFSA) investigated the influence of catechins contained in green tea, particularly epigallocatechin gallate (EGCG), on hepatotoxicity (liver toxicity). Green tea consumption results in an average daily intake of 90 mg to 300 mg of EGCG. This intake is considered safe.High tea consumption can result in the intake of up to 866 mg EGCG/day. Daily consumption of more than 800 mg EGCG resulted in an increase in liver enzyme levels after 4 months. In clinical studies, daily intake below 800 mg EGCG for a period of 12 months showed no effect on the liver. Traditionally produced green tea consumed in excess of 5 cups or 700 mg EGCG/day also had no effect.