Products
Epirubicin is commercially available as a concentrate for injection/instillation (farmorubicin, generics). It has been approved in many countries since 1993.
Structure and properties
Epirubicin (C27H29NO11, Mr = 543.5 g/mol) is structurally closely related to doxorubicin.
Effects
Epirubicin (ATC L01DB03) is antineoplastic. It is an anthracycline antibiotic, rapidly penetrates the cell, binds to DNA, and inhibits nucleic acid synthesis and cell division via inhibition of DNA topoisomerase II and DNA helicase.
Indications
- Breast carcinoma
- Malignant lymphoma
- Soft tissue sarcomas
- Gastric carcinoma
- Bronchial carcinoma
- Ovarian cancer
- Urinary bladder carcinoma